![]() ![]() Photo credit: Mark Hanson at Mark Joseph Studios. W., A Photostable Silicon Rhodamine Platform for Optical Voltage Sensing. J Am Chem Soc 2015, 137 (33), 10767-76. W., Isomerically pure tetramethylrhodamine voltage reporters. J Am Chem Soc 2016, 138 (29), 9085-8. All the Latin audio here is carefully read in restored classical pronunciation. "Voltage Imaging: Pitfalls and Potential." Biochemistry, 2017, 56, 5171-7. On Reading Latin - by Evan Millner Moss wrote something that got me thinking - his statement that he wasn't going to be reading much of that mediaeval or renaissance Latin anytime soon - which is, I think, a rough paraphrase of what he was trying to say. "Fluorogenic Targeting of Voltage-Sensitive Dyes to Neurons", J Am Chem Soc, 2017, 139, 17334-40. Imaging Ca2+ with a Fluorescent Rhodol. Biochemistry, 2018, 57, 237-40. Plus 100,000 AM/FM radio stations featuring music, news, and local sports talk. Stream live CNN, FOX News Radio, and MSNBC. In Vivo Two-Photon Voltage Imaging with Sulfonated Rhodamine Dyes. ACS Cent Sci. 2018, 4,1371-1378. Listen to free internet radio, news, sports, music, audiobooks, and podcasts. Spying on neuronal membrane potential with genetically tar-getable voltage indicators. J Am Chem Soc. 2019, ASAP. "New Molecular Scaffolds for Fluorescent Voltage Indicators." ChemRxiv. 2018, Preprint. "Optical determination of absolute membrane potential." bioRxiv. 2019, Preprint. Throughout, these approaches will be integrated into systems ranging from primary cell culture to tissue slices to whole animals in order to not only show-case the utility of our new tools, but also to explore new dimensions of neuronal communication and information transfer. Secondly, we will investigate new synthetic and genetically encoded indicators for optically monitoring voltage changes in neurons. First, we will develop activity-dependent neuronal tracer dyes for following signal transduction through neural circuits and within cells. This approach to studying neuronal communication and information flux in the brain is two-pronged. ![]() We seek to address how the brain transmits information from cell to cell and develop tools to track neuronal activity with high spatial and temporal resolution. This multi-faceted approach engages a diverse group of researchers from differing scientific backgrounds, both expanding our understanding of basic chemical and biological processes and using these discoveries to investigate the brain. I have hundreds of Latin videos on my YouTube channel, using restored classical pronunciation, and links to other Latin audio resources with hundreds of hours of Latin audio, in addition to articles I have written. We seek to exploit expertise in synthetic chemistry, probe design, imaging, molecular biology, and electrophysiology to create and deploy molecular tools for mapping brain activity. Research in the Miller lab operates at the interface of molecular and cell biology, synthetic chemistry, and neuroscience. Associate Professor of Biochemistry, Biophysics and Structural Biology*įull Directory Information Research Interests ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |